Power ultrasound facilitates controlled and reproducible crystal nucleation which is fundamental in controlling crystallization of pharmaceutical ingredients. Sonocrystallization delivers controlled nucleation and superior control of particle size, morphology, polymorphism, crystallinity and purity, and in doing so helps eliminate the need for troublesome external seeding of bulk processing, and deleterious effects of micronization on input materials for  inhaled medicines including poor performance and limited product shelf-life.