Controlling and actively manipulating nucleation and subsequent crystal growth behaviour is fundamental to the improvement of a crystallization process. Prosonix achieve this through the selective application of ultrasound, via patented scale-out technology Complete Crystallization Control(™) and developed procedures.  

Our customers benefit from the control of crystal habit, amorphous state, crystallization of the ground-state polymorph form and/or preferential forms, manipulation of crystal size distribution, prevention and reversal of agglomeration and improvements in related product properties such as purity, filtration rate and bulk density. These tangible value-added benefits arising from the control of physical form are capitalised at production scale because process repeatability is increased as a result of controlling the point of nucleation and the approximate number of nuclei generated.

Significant value-added benefits are capitalised through new process patents that can be created for individual products, thus securing and extending marketing timescales.

An attractive business feature of the Prosonix technology is that it can be applied at ANY STAGE in a product pipeline. The technique can be used in early laboratory studies through to full industrialization. This scale-out feature of the technology ensures that success in the lab can be replicated across scale.

Almost all chemical processes utilise at least one crystallization step, either as the key separation mechanism or final polish filtration. Crystallization has been described as one of the most difficult unit operations to control, irrespective of whether the process utilises cooling, evaporative, anti-solvent or pH shift.

Prosonix has developed a suite of proprietary technologies which use power ultrasound to control the crystallization process and allow the precise production of high purity organic and inorganic microcrystalline chemicals - be they intermediates, excipients, API's, binders, sugars or colorants.

The technology is available for use on a commercial scale and is already validated across scale in GMP environments.

Prosonix technology can be used in in-line continuous flow mode, or batch mode for in-situ generation of seed crystals using the process liquid itself as the source for the seeds, thus overcoming one of the major limitations of classical seeded processes.