Prosonix Advanced Particle Engineering (APE) technologies span all aspects of the pharmaceutical development pipeline from discovery through to process optimisation / manufacture and formulation / drug delivery with the prime objetive of manufacturing better medicines.

Collaborative Research and Process Development

Using Prosonix proprietary technologies and expertise our dedicated team of chemists and chemical engineers, in our laboratories in Oxford, are able to offer a variety of research services, in house training and products developed to suit our customers needs. This will allow our clients to enhance their own ultrasonic capability and optimize  current solid-state primary and secondary manufacturing processes.

Proof of Concept / Proof of Process studies

This is the initial stage of evaluation and investigation and can take the form of in-house crystallization and particle engineering studies looking at:

• * Polymorphism, habit and crystal size selection
• * Production of micro and nano-crystalline pharmaceutical materials
• * Sono-milling for particle size reduction and de-agglomeration
• * Dispersion enhancement
• * Process development and optimization towards cGMP manufacturing
• * Actual cGMP production of crystalline pharmaceutics including inhaled medicines
• * Novel sonoprocessing
• * Ultrasonic training programmes' for scientists and engineers from partner companies

Proprietary Prosonix Equipment and Automated Equipment

* Prosonitron^TM flow and batch reactors 5, 10 & 20L, engineered for ATEX environments and suitable for commercial pharmaceutical use
* SonoLab^TM reactors and flow-cells up to 2.5L
* SAX^TM (Solution Atomization and Crystallization by  Sonication)
* DISCUS^TM (Dispersive Crystallization with Ultrasound)
* 1, 2, 5, 10 and 20L temperature controlled reactors
* Syrris Atlas K 0.5 – 1L automated reactors
* HEL-AutoLAB Bench Scale Reactor Systems - 1L automated reactor with flow cell and online Lasentec (FBRM) and turbidity analysis
* HEL- PolyBLOCK Multizone Reaction system - 4 x 70ml parallel crystallization workstation with online turbidity analysis and manual reactor set-ups with sonication control
* Buchi and SonoTek laboratory spray dryers fitted with both twin fluid nozzle and ultrasonic atomization

Analytical Suite

* Malvern Mastersizer 2000 Particle size analysis
* Lasentec FBRM (Focused Beam Reflectance Measurement) probe for use online, in-progress particle size analysis
* Nikon Optiphoto Microscopy with high definition digital image processing
* Siemens D5000 powder diffractometer (Oxford Material Sciences)
* Mastersizer 2000 particle size analyzer
* Sympatec HELOS BF, RODOS & ASPIROS
* Nanotrac NPA 252 (Honeywell Microtrac Systems)
* Dynamic Vapour Sorption DVS: Intrinsic (Surface Measurement Systems)
* Differential Scanning Calorimetry: DSC Q2000 (TA Instruments)
* Thermo Gravimetric Analysis: TGA Q50 (TA Instruments)
* Scanning Electron Microscopy: JEOL JSM 6480LV (Oxford Material Sciences)
* Access to Raman, AFM, NMR

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Combined expertise in:

* Sono-crystallizations
* Particle engineering
* Organic Synthesis and sono rate enhancement
* cGMP manufacturing and process development
* Manufacturing scale-up
* Drug delivery systems and bioavailability enhancement
* Focussed screening experimentation
* Computational chemistry and molecular modelling
* Design of Experiments methodology (DoE)
* Complex statistical data analysis
* Engineering CAD and development

CAD images above show the Prosonitron 5 and 7.5L Hastelloy High Density Reactor system, shown with their outer casing partially removed to visualize the bonded transducers. The Prosonitron is available in ATEX design for flammable solvent use and also in different materials of construction to suit the customers’ process environment.

For your primary and secondary crystallization processing and particle engineering partner with Prosonix today.